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And chronically, over time, especially on a backdrop of a high-stress lifestyle, perhaps leads to more systemic inflammation and poorer health outcomes
158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects
This is noteworthy as (1) many biologically active peptides contain an -helix (a large fraction of PPIs involve an -helix) and (2) those helix portions could potentially be replaced or partially replaced by oligoureas with minimal effect on the binding while improving the proteolytic resistance of the peptide
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